Alzheimer’s Brain: What Happens In A Brain With Alzheimer's Disease?
Aging typically brings with it many physical, cognitive, and emotional changes. While some of these changes can be treated and managed with medical care, Alzheimer’s disease is a condition that may not be addressed as easily. It usually involves changes in the brain that can affect memory and cognitive functioning. Neurofibrillary tangles and beta-amyloid plaques are often thought to contribute to the damage of neurons that is usually seen in those with Alzheimer’s disease. While medical care is often crucial for those living with this disease, it can also be vital to seek mental health care in the form of in-person or online therapy. Comprehensive treatment can help those living with Alzheimer’s disease to receive the support they deserve.
Normal brain vs. Alzheimer’s brain
The brain can be considered your body's most influential and critical organ because it generally runs all the other parts of your body, enables you to think, retains your memories, and governs your personality. The average brain weighs approximately three pounds and has a texture similar to a firm jelly substance. It is generally comprised of three main parts:
- The cerebrum may be the most significant part of the brain. It typically controls cognitive functions, such as problem-solving, remembering, thinking, and feeling, as well as the ability to move.
- The cerebellum is normally located at the back of the head and controls general coordination and the ability to balance.
- The brain stem is generally located below and in front of the cerebellum. It normally serves to connect the brain and spinal cord and can be responsible for controlling crucial automatic body functions. These usually include breathing, heart rate, blood pressure, and digestion.
Your brain is normally provided with oxygen from your blood. With each heartbeat, your arteries may carry approximately 20% to 25% of the blood in your body to your brain. Ultimately, your brain can use about 20% of the blood’s oxygen. When you are intently concentrating, your brain may use up to 50% of the oxygen flowing through your body.
All that oxygen may be needed because of the billions of cells in your brain. Those brain cells may constantly work to keep you alive and carry out various cognitive processes. Different parts of the brain are usually dedicated to specific tasks. Examples of these functions can include processing outside stimuli, interpreting sensations, making plans, initiating action, and moving the body.
Impairment in the hippocampus and cognitive memory
The hippocampus is a part of the brain that can transfer information into long-term memory, and it can be of particular importance in Alzheimer’s disease. This part of the brain's limbic system usually assists with knowledge and forming memories. Damage to the hippocampus can impair the ability to create new memories.
How does Alzheimer's affect the brain?
No matter what part of the brain is in action, the brain's work is typically done by individual cells. Branches may connect these nerve cells, or neurons. The units of cells can be referred to as axons. Signals can travel along these axons to carry messages from one neuron to another. In a brain with Alzheimer's disease, the neurons can become damaged and eventually destroyed. This can disrupt and impair the way that signals move through the brain.
Neuron damage and beta-amyloid plaques
Researchers think this neuron damage may happen because of two processes. One may be the formation of neurofibrillary tangles. These are usually made up of twisted strands of the protein tau. The tau is generally supposed to be in lines or tracks to transport nutrients. However, it can collapse into tangles, meaning that nutrients can no longer go to the nerve cells, which can cause them to die.
Second, beta-amyloid plaques, or abnormal cluster protein fragments, can also build up between the brain's nerve cells. Research indicates these plaques can block signaling in the brain's nerve cells.
Cause of changes and plaques
Scientists are not entirely sure what causes these changes in the brain. However, some changes appear to result from genetic and environmental factors. For example, research shows that a genetic mutation can increase levels of risk. Studies have also found that a head injury sustained earlier in life may also increase the risk of developing Alzheimer’s disease.
Hippocampus and cerebral cortex: What part of the brain does Alzheimer’s affect?
As noted above, the hippocampus is normally the part of the brain responsible for putting information into long-term memory. This part of the brain is usually necessary for this process. If the hippocampus becomes damaged, it can severely affect memory. Generally, after hippocampal damage, people are unable to form new memories. This can result in individuals “living in the past” if they still can remember their old memories. Conversely, this can result in individuals living only in the present moment, as they may immediately forget information.
Memory and cognitive impairment in the cerebral cortex
Alzheimer’s disease tends to be the single most common cause of dementia and, according to the DSM-5, may account for 60% to over 80% of all cases. Alzheimer’s disease usually affects the hippocampus first. This part of the brain tends to be the most severely affected by the condition. The disease may then move through several stages, with symptoms typically worsening over time as the neuron damage spreads throughout the brain's cortex. This may be why memory is often the first cognitive function to be affected, and over time, other functions may also be impacted as the damage increases.
How is Alzheimer's disease diagnosed?
Brain scans and similar procedures may help doctors diagnose Alzheimer’s disease, as can a presentation of relevant symptoms. As neurons send signals to the brain, it can lead to thoughts and behaviors. This neuronal firing can also create memories and play a role in personality. Neurons often fire in patterns for certain activities. These patterns can be seen in brain scans, such as a Positive Emission Tomography Scan (PET Scan). If someone's brain is scanned while doing different activities (such as reading or solving math problems), different activity patterns can be observed.
Alzheimer’s brain scan
Alzheimer's brain scan results would likely show different patterns than what might be expected from a healthy brain. This is generally because of the changes in neuron function due to the damage from the plaques and tangles built up in the brain.
However, Alzheimer’s disease may not usually be diagnosed by a brain scan alone because other conditions could also account for those changes in brain activity. It can be tricky to determine what’s truly going on in the brain while a person is living. Historically, Alzheimer’s disease was generally diagnosed with certainty after a person passed away.
Alzheimer disease: Ruling out other neurodegenerative disorders
As a result, sometimes the best course of action can be to perform tests to rule out other potential conditions. When no other diagnosis fits the symptoms, then a diagnosis of Alzheimer’s disease can be used to label the condition. Genetic testing may also show a genetic mutation that could support the diagnosis, although that is not always definitive.
Are you or a loved one experiencing memory loss?
Alzheimer’s brain: How to get professional support
If you’ve received an Alzheimer’s diagnosis, are close to someone who has, or are generally concerned about your health, it can be beneficial to speak to both a doctor and a mental health professional for insight. Receiving a proper diagnosis and adequate support can help you feel better prepared to address any changes that might come your way.
After a confirmed diagnosis
Suspecting a diagnosis of Alzheimer’s disease can be upsetting. Once a diagnosis is confirmed, there can be grief, anxiety, and depression about the situation. Someone in this situation may seek therapeutic support to help them adjust and cope. Frequently, those with Alzheimer’s disease eventually rely on family as caregivers.
Benefits of online therapy for Alzheimer and other neurodegenerative disease
Whether you’re living with Alzheimer’s yourself or are close to someone who is, you may be able to benefit from services like online therapy. This type of platform generally allows you to get the care you deserve at a time and from a place that works for you. Whether it be from the comfort of your own home, the office, or somewhere else that brings you peace, you can have control over the environment in which therapy takes place.
Effectiveness of online therapy
Aside from its convenience, online therapy can be a truly beneficial treatment option. According to a 2023 study, internet-based cognitive behavioral therapy can be effective in treating depression symptoms in those living with chronic conditions, such as Alzheimer’s disease.
Takeaway
What exactly does Alzheimer's do to the brain?
Alois Alzheimer is credited with discovering Alzheimer’s disease in the early 1900s. Since then, doctors and researchers have learned much about the disease. We now know that it is the most common cause of dementia and the seventh leading cause of death in the United States. Understanding Alzheimer’s is important, which is why there is ongoing research and clinical trials related to the disease.
Alzheimer’s disease may begin with mild cognitive impairment, but the patient may soon begin experiencing cognitive decline. Small memory lapses or difficulty finding a common word might be among the first symptoms of early Alzheimer’s. Other symptoms occur as the disease progresses, including personality changes, confusion, and mood swings. At this stage, a doctor may need to make a formal diagnosis and differentiate the symptoms from those of vascular dementia or other types of dementia.
As Alzheimer’s worsens and dementia symptoms progress, the person may experience serious memory loss. This is usually indicative of the last stages of Alzheimer’s. The most severe stage consists of significant physical impairments that affect the person’s ability to speak, move, or eat.
Researchers believe that Alzheimer's disease damages and eventually destroys neurons or brain cells, causing cell death and causing the brain to lose connections. This damage may be caused by the formation of neurofibrillary tangles, twisted strands of a protein called tau, and other cellular debris. Tau proteins are supposed to transport nutrients throughout the brain tissue. Another possible cause of the damage in Alzheimer’s is beta-amyloid plaques building up between nerve cells, brain changes that can block the signals in the brain and even affect blood vessels.
How does Alzheimer's take your life?
Alzheimer’s kills cells in the brain. While this may be limited to one particular region at first, it slowly spreads to other areas of the brain. Alzheimer’s generally starts in the brain area associated with memory, the hippocampus, and then spreads to form plaques in the cerebral cortex, the part of the brain involved in memory, learning, thinking, reasoning, emotions, problem-solving, and consciousness. This damage will eventually spread to deep regions of the brain, where it can inhibit core body functions, like breathing and heart rate, which leads to death. Complications of Alzheimer’s, like falls, respiratory infections, or urinary tract infections, can also lead to death as the disease progresses, but care for these conditions has improved over the years, and the death of brain cells is now more likely to be fatal.
Do people with Alzheimer's know they have it?
People with Alzheimer’s may be aware of their symptoms early on but consider them as typical of healthy aging before recognizing that something is wrong. As they progress, they are less and less likely to understand or even be aware of their condition. Still, early diagnosis is important. Beginning treatment during the early stage of the disease can improve a person’s quality of life as the disease process continues. Here are some early signs of Alzheimer’s disease to be aware of:
- Memory problems like forgetting important dates
- Getting lost or confused when out in public
- Forgetting words or using a smaller vocabulary
- Depression and other mood changes
The presentation of dementia ranges from person to person, but these are some of the more common symptoms.
What happens before an Alzheimer's patient dies?
Late-stage symptoms of Alzheimer's disease affect the person in many ways. If someone with Alzheimer’s does not die of complications and the disease progresses to end-stage, the damage may prevent patients from doing even simple movements. They may not be able to speak, eat, or drink, and they may be unable to shift their position in bed, which can lead to bedsores. Seizures may occur, and the person may sleep for long periods and develop shallow breathing or take prolonged periods between breaths.
How long does a person with Alzheimer's usually live?
The average life expectancy for someone over 65 with Alzheimer’s is between four and eight years. Some people can live up to 20 years after the appearance of the initial symptoms. As the disease progresses from moderate Alzheimer’s disease to more severe stages, neurons and other cells in the brain will eventually die, leading to a decline in brain function.
What does someone with Alzheimer's think about?
In the early stages of the disease, a person with Alzheimer's disease may continue to think in the same way that they usually would, with periodic moments of forgetfulness. Knowing what people with Alzheimer’s think in later stages or if they even do is challenging to say as they may lose their ability to communicate effectively or process information.
What does it feel like to live with Alzheimer's?
Alzheimer’s progression is different for everyone. Some people with the disease report having good and bad days. Others have early symptoms, like difficulty finding words or learning new things, significantly impacting their lives.
If you think you’re experiencing signs of Alzheimer’s disease, it can be important to know the risk factors. Here are some of the lifestyle factors and other factors that may put you at a higher risk to develop Alzheimer’s:
- Smoking
- Social isolation
- High blood pressure
- Age
- Family history
- Depression
- Having Down syndrome
- Using some anti-anxiety medications
You can lower your risk factor for developing Alzheimer’s by adopting a healthy lifestyle and having standard medical tests as you age.
What is the longest stage of Alzheimer's disease and dementia?
The middle stage is usually the longest, and it can last several years. Alzheimer’s progresses differently for everyone, though, so the longest stage for one person may not be for another. Researchers believe that many things contribute to how fast Alzheimer’s and related dementias progress, including genetic factors, comorbidities, and sociodemographics.
At what stage do Alzheimer's patients sleep a lot?
Sleeping more may be a feature of later-stage Alzheimer’s dementia. As the disease progresses, the damage becomes more and more extensive. They become weaker and may get tired by simple activities like eating or talking.
At what stage do dementia patients forget family members?
In the middle stages, people with dementia may begin to confuse one family member for another. As the disease progresses, they may begin forgetting the names of their family members and stop recognizing them. Family members may benefit from talking to a therapist or getting some related dementias education from local and national resources as the progression of this disease can be challenging to deal with. In late stage or severe Alzheimer’s disease, patients may begin to lose some of their physical functionality, such as the ability to eat.
Dealing with a family member’s dementia
Dementia is a neurocognitive disorder that has something to do with the loss of memory, language, and thinking abilities that are severe enough to interfere with their lives. If you have a loved one with dementia, the best thing you could do is support and assist them throughout, while still maintaining their space and boundaries. Empathize with them, and provide them with the proper treatment and care they need.
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