What Is Discontinuation Syndrome And What Should I Do About It?

By: Julia Thomas

Updated March 18, 2021

Medically Reviewed By: Kimberly L Brownridge , LPC, NCC, BCPC Counsel The Mind, LLC

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Depression is a difficult and sometimes even life-threatening disorder. For many people with depression, antidepressant medication makes a dramatic improvement in the quality of life. These medications are powerful in other ways, too. If you don't take them according to your doctor's instructions, you may experience discontinuation syndrome.

What Is Antidepressant Discontinuation Syndrome?

Discontinuation syndrome is a physical reaction to stopping an antidepressant medication abruptly. This syndrome can cause changes in your body and brain that cause you to feel unwell physically and mentally. Doctors typically take you off an antidepressant gradually to avoid or minimize discontinuation syndrome.

Is Discontinuation Syndrome The Same As Withdrawal?

In the past, discontinuation syndrome was referred to as 'withdrawal effect.' This gave the idea that antidepressants were harmful drugs. More recently, the term 'discontinuation syndrome' has come into use.

The reason for the change is that what happens is different from the withdrawal effect you have from an addictive drug. Antidepressants aren't addictive. People who are on them don't engage in drug-seeking behaviors.

What happens with discontinuation syndrome is that the brain doesn't have the medication it's accustomed to having to help perform its normal function in mood control. When the medication is no longer there, the neural natural processes must take back over the job completely. This can happen gradually and relatively painlessly when your doctor tapers down the dose, or it can happen abruptly, which causes the symptoms of discontinuation syndrome.

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Symptoms Of Discontinuation Syndrome

Recognizing the symptoms of discontinuation syndrome can make your life much easier. When you know what's happening, you can get help from your doctor. If you suspect it's happening, you can check your medications to make sure you've taken them as prescribed. If not, you can simply start taking them again, at least until you talk to your doctor.

It's easy to remember the main symptoms of this disorder. Doctors use the mnemonic device 'FINISH' to help you remember each type of symptoms you might have.

Flu-Like Symptoms

You might have symptoms you'd normally associate with having the flu. These can include a headache, lethargy, diarrhea, and appetite disturbances.


Sleep disturbances tend to go with the territory when you stop taking medications too abruptly. You might have insomnia or be woken up often by nightmares.


Nausea is bad enough, but you might also have related symptoms, such as abdominal cramping, abdominal pain, and vomiting.

Imbalance And Movement Problems

You may have a hard time keeping your balance. Dizziness, lightheadedness, and vertigo may cause you to feel unstable and ready to fall or collapse. Movement problems can include akathisia (a feeling of agitation and restlessness), twitches, jerks, tremor, or Parkinsonian movements.

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Sensory Disturbances

Sensory disturbances typical with discontinuation syndrome include blurred vision, nerve feelings like your being shocked with electricity, numbness, and paresthesia, which is that pins and needles feeling that comes with pressure on a nerve.


Hyperarousal is extreme alertness. When this happens, you feel every sensation as if it was multiplied many times. You may experience unusual emotions, such as agitation, irritability, anxiety, or sadness.

Other Symptoms

In extreme cases, you could experience severe symptoms. These are rare, but extremely important to address immediately. They include psychosis, catatonia, delirium, delusions, and hallucinations. As discontinuation syndrome symptoms, these are sometimes but rarely seen with MAOI antidepressants.

Symptoms Tend To Differ With Different Medications

Depending on the antidepressant you've been taking, you may experience different symptoms than someone else or than another time when you discontinued a different antidepressant. For example, SSRI discontinuation syndrome symptoms are dizziness, gastrointestinal upset, lethargy, anxiety, low mood, sleep problems, and headaches.

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When Does Discontinuation Syndrome Happen?

Discontinuation syndrome, when it happens, usually happens within three days after you stop your medication abruptly. Sometimes, it can happen with hours of the first missed dose. The symptom usually runs its course in one to two weeks.

Length Of Treatment Time

Whether you'll have discontinuation syndrome and whether it will be mild or severe depends partly on how long you've been taking the antidepressant. It doesn't usually happen unless you've been on the medication at least six weeks before you discontinue it. If you've been on it for many months or even years, your chances of having severe symptoms are increased.

Medication's Half-Life

Abruptly stopping a medication with a short half-life is more likely to result in symptoms. So, what is a drug's half-life? The half-life is the amount of time it takes for the amount of the drug in the body to be reduced by one-half.

For example, Zoloft discontinuation syndrome is less likely than Cymbalta discontinuation syndrome in this regard, because Zoloft has a half-life of 26 hours, while Cymbalta has a half-life of only 11-16 hours.


If you've been taking a high dose of an antidepressant, you're more likely to have discontinuation syndrome than if you've been taking a low dose.

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Why Would I Stop Taking My Antidepressant?

If you've just started taking an antidepressant, chances are you see some need for it. And, when you first start out, it may be easy to remember to take it, because it's something new and not something you're so used to that you don't think much about it. You may wonder why, when you chose to take the antidepressant in the first place, you would decide to stop taking it suddenly. It can happen in a couple of different ways and for many reasons.

Accidental Discontinuation

You might go along fine, taking your medications as directed. One day, you forget to take your antidepressant. One day can turn into several, and the medication can get completely out of your system, causing discontinuation symptoms. This often happens when you're taking several medications and take them each day directly from their bottles.

Lack Of Medication

Discontinuation syndrome may happen simply because you don't have the medication when you need it. If you have sudden financial problems or you may just as suddenly run out of medication. You may run out for other reasons, too. For example, if you don't drive and someone else usually picks it up, you are in a bad position if they suddenly can't or won't take care of it.

Purposeful Discontinuation

At some point, you might decide not to take the medication anymore. Maybe it's done its job wonderfully. You're no longer depressed, so you don't feel the need to keep taking the medication. Or, you might not like taking the medication because doing so makes you feel like you aren't normal. Sometimes antidepressants can cause you to shift into mania if you have bipolar disorder. You may stop the medication in a desperate attempt to regain control.

How Dangerous Is Discontinuation Syndrome?

For most people, discontinuation syndrome isn't dangerous at all. It's certainly uncomfortable. If you don't know what's going on, it can be alarming. But, it rarely causes any problems you can't live with for the couple of weeks it takes for the syndrome to fade away.ost people, discontinuation syndrome isn't dangerous at all. It's certainly uncomfortable. If you don't know what's going on, it can be alarming. But, it rarely causes any problems you can't live with for the couple of weeks it takes for the syndrome to fade away.

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There are very rare instances when severe symptoms can happen because of the physical effect of stopping the medication. Also, you may relapse and become depressed again. If that happens, the original disorder (such as depression) may cause problems.

What To Do About Discontinuation Syndrome

The first thing to remember if you suspect you have antidepressant discontinuation syndrome is not to panic. You can deal with this, and your doctor is there to help. The most common symptoms are mild. In most cases, it will pass within a week or two without you doing anything about it.

Still, you can improve your situation in two ways: by starting the medication again and by seeing your doctor.

Start Taking Medication Again

Unless you have shifted into the manic phase of bipolar disorder, you may be able to put an end to the discontinuation symptoms without much help. Simply start taking the medications again as directed. This is usually the best course of action if you've only missed a few days or less. Then, when you see your doctor again, let them know what happened and what you did about it.

See Your Doctor If You Recognize The Symptoms

When you realize you may be suffering from discontinuation syndrome symptoms, it's best to talk to your doctor to find out if you need to be seen immediately. You'll need your doctor's help in some cases, especially if you have severe symptoms or want to stop the symptoms of discontinuation syndrome faster.

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Seeing your doctor is doubly important if you aren't sure it's discontinuation syndrome or if starting back on the antidepressant doesn't help. It may turn out that you have a different condition that has similar symptoms. If restarting the med doesn't help, you'll need your doctor's recommendations on what to do next.

Organize Yourself To Take Medications More Regularly

If you forget your medications often, it may be because you've never developed a system for making sure you take them. You can start by getting a pill box that has different compartments for each day of the week. Fill it every week and take from the designated compartment each day. If you're unsure whether you've taken it, just check to see if the compartment is empty.

Another thing you can do to make sure you take your antidepressant is to set reminders. You can set a daily reminder on your smartphone, laptop, or tablet. Then, take the medication as soon as possible after the reminder tone sounds.

Talk To Your Doctor Before Discontinuing A Medication

You can prevent or minimize the effects of discontinuation syndrome by talking to your doctor before stopping an antidepressant. Your doctor can give you a specific schedule for reducing the medication gradually if you decide you aren't going to take it anymore. They can also let you know what to expect as you reduce your dosage. In some cases, they might strongly suggest that it isn't the best time to stop the medication. In any case, having a frank discussion with your doctor can help you prevent problems now and in the future.

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Talk To A Counselor To Resolve Your Mental Health Issues

Medication isn't always the best answer, and it's rarely the total solution. In most instances, therapy can improve your success with antidepressants. What's more, a therapist can help you understand the risks of stopping medications abruptly and the rewards of taking care of your mental health issues.

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