How To Choose An Effective PTSD Treatment

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Post-traumatic stress disorder (PTSD) affects millions of Americans and can cause symptoms that adversely impact work, relationships, and daily life. PTSD can be complex and includes biological, psychological, and social components. The condition is often treated with talk therapy or medication. If you're looking to decide which type of PTSD treatment is most effective for you, there are a few options to consider.

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The effects of PTSD

The brain of a person with PTSD shows marked differences from a person without the condition. For example, brain imaging shows increased activity in the amygdala, the brain area controlling the fight or flight impulse that occurs when individuals are faced with danger. Brain imaging also shows changes in how the amygdala is integrated with the prefrontal cortex, the brain region responsible for rational thinking and judgment.

This altered brain structure partially explains the four symptom clusters that The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) describes as criteria for a PTSD diagnosis, including the following: 

  • Re-experiencing symptoms: Re-experiencing the traumatic event through nightmares, physical reactivity, distressing memories, and flashbacks 
  • Avoidance symptoms: Avoiding trauma-related stimuli, including external reminders, such as specific places, conversations, or objects, and internal reminders, such as thoughts and emotions
  • Cognitive symptoms: Unwanted thoughts or feelings, such as blaming oneself. The person might also demonstrate negative attitudes about the world or others 
  • Arousal symptoms: Changes in arousal levels, such as feeling on edge, irritability, increased anger, difficulty concentrating, hypervigilance, or easy startle  

Without treatment, some people’s symptoms may gradually lessen, while others may experience worsening symptoms or even physical medical problems, like hypertension.

Psychotherapeutic treatments for PTSD

Successful treatment for PTSD can depend on the individual. However, a few factors may influence the success of treatment.

According to the US Department of Veterans Affairs (VA), the most effective first-line treatments for PTSD are cognitive-behavioral therapy (CBT) and eye movement desensitization and reprocessing (EMDR). Other therapies for PTSD may include prolonged exposure therapy and cognitive processing therapy (CPT). 

In some instances, symptoms may be so severe they interfere with psychotherapy. Effective therapy often requires "talking through" or "remembering" traumatic memories, and this experience may be difficult or impossible for some people. In cases like these, medications might ease symptoms so an individual can focus on the treatment plan their therapist builds for them. 

Consult your mental health and medical team before starting, changing, or stopping a medication. The BetterHelp platform is not intended for any information regarding which drugs, medication, or medical treatment may be appropriate for you. The content provides generalized information that is not specific to one individual. You should not take any action without consulting a qualified medical professional.

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Questions to consider about PTSD medications

The decision to take medication can be complicated because there are various medication options, and each one has potential side effects to discuss with your doctor. In addition, starting a new medication can be scary, and you may be taking a risk to see whether the benefits outweigh any potential adverse effects.

The following questions can be considered as you contemplate which PTSD medication may be effective for you alongside your doctor's advice: 

  • Do you have other mental health problems besides PTSD, like panic disorder or major depressive disorder, that medication also might treat? 
  • Are you prepared to handle potential side effects on the road to recovery?
  • Have you tried medication before, and what was your experience?
  • Do you have any health conditions that may contraindicate using some medications, such as hypertension, diabetes, pregnancy, or others?
  • Do you drink alcohol regularly or use any illicit recreational substances that might interact with medications?
  • Which PTSD symptoms are bothering you the most?
  • What is your goal for recovery?

Thinking about these questions before talking to your doctor may help you articulate your concerns about the type of medication that might be most helpful in your situation. You might also discuss whether medication is not for you, as some people may not find this solution helpful. 

Types of PTSD medications

Although the following sections discuss specific medications often used to treat PTSD symptoms, this article does not replace a doctor's or psychiatrist's medical advice. Do not take any medication without a prescription from a medical doctor. Consider asking for a second opinion from your doctor if you've made a decision based on the information below.

Doctors can prescribe various medications for PTSD symptoms. These medications can include some of the same options that have proven effective in treating other mental health conditions, such as anxiety disorders and depression. Below are a few broad categories and specific medications that might be used, along with their pros and cons that you can discuss with your doctor.

Selective serotonin reuptake inhibitors (SSRIs)

SSRIs are often recommended to treat mood disorders, anxiety disorders, and trauma and stressor-related disorders, like PTSD. These medications work by altering serotonin levels in the brain, which plays a central role in mood control. 

Currently, only a couple of SSRIs are approved by the FDA for the treatment of PTSD. However, doctors can prescribe other medications off-label if they deem it beneficial. This research indicates insufficient evidence for the FDA to approve other SSRIs for PTSD, but there is a panel consensus that these medications are safe and effective for some people. 

Not every client may experience success using SSRIs to treat PTSD. Some might experience side effects, which can be challenging. Side effects can include headaches, sexual dysfunction, and suicidal ideation. Doctors may also prescribe a similar type of medication called serotonin-norepinephrine reuptake inhibitors (SNRIs), which cause combined serotonin reuptake inhibition and norepinephrine reuptake inhibition. These medications can be more effective than SSRIs in some cases, but they also tend to cause more side effects for some individuals. 

If you are experiencing suicidal thoughts or urges, call the National Suicide Prevention Lifeline at 1-800-273-TALK (8255) or text 988 to talk to someone over SMS. Support is available 24/7.

Not everyone experiences side effects from SSRIs, and if they do, the adverse effects might be mild compared to the relief these medications offer. Studies have shown that 60% of clients find some relief from their symptoms by using SSRIs and SNRIs. However, only 20% to 30% achieve complete remission using medication alone. In addition, if you decide to take an SSRI, it can take six to eight weeks for the medicine to begin working. These results may vary per person. 

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Monoamine oxidase inhibitors (MAOIs)

MAOI medications work by blocking the removal of norepinephrine, serotonin, and dopamine from the brain. They are sometimes prescribed for anergic bipolar disorder, atypical depression, depression that is resistant to other medications, and PTSD. Although these medications may effectively help individuals manage PTSD and depressive disorders, they are not first-line medications due to safety issues and severe side effects. However, if SSRIs are not working and side effects like high blood pressure can be closely monitored, MAOIs may be worth discussing with a provider for people with PTSD. 

Some clients who take these medications experience fewer symptoms of avoidance, flashbacks, nightmares, and insomnia. MAOIs may cause hypertension and can interact dangerously with substances, so consult a doctor before taking them. 

Beta-blockers

Beta-blockers block norepinephrine at the brain synapses and block adrenaline from entering organs such as the muscles and the heart. They might reduce hyperarousal and aggression and can improve symptoms of severe anxiety for some individuals. Talk to your doctor about whether these medications may benefit you. Some beta-blockers can cause dependency, so discuss these risks with your provider before taking them. 

Counseling options 

Some medications may offer support for clients experiencing PTSD or co-occurring mental illnesses. In some cases, a doctor might ask their client to try a prescription for a short time and then switch to another. In other cases, doctors prescribe more than one medication for PTSD and find they can complement each other.

There is no single answer for treating PTSD symptoms, and medications can help temporarily. However, a compassionate and qualified therapist can also be an option in helping you overcome the physical, emotional, and social symptoms of PTSD. Often, medications are short-term, whereas therapy can have long-term impacts. However, note that only a doctor, like a psychiatrist, can prescribe them. 

If you're worried about attending therapy due to the cost, distance, or availability, you might also benefit from online counseling. Research shows that online therapy can be effective in treating PTSD. PTSD symptoms include anxiety symptoms that might be easier to manage when talking to a therapist through an online platform. In addition, online therapy has the benefit of being easy to reach from home or any other location with internet connectivity, which can make a significant difference for people with PTSD.

If you're interested in getting started, you can work with an online platform like BetterHelp, which has over 30,000 licensed therapists, counselors, and social workers specializing in various areas of mental health, including PTSD. 

Takeaway

PTSD is a mental illness caused by the experience of a traumatic event or multiple events. Various medications may help people gain control of their symptoms, although some could have unpleasant and dangerous side effects. If you're considering medication, consult your primary care physician or psychiatrist for further guidance. If you're looking into a non-medical form of treatment for PTSD, consider talking to a therapist.

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