Do Antidepressants Make You Happy?

By: Tiffany Bailey

Updated February 20, 2020

Antidepressants are commonly prescribed to treat mental health conditions that are impairing a person's ability to function in their daily lives. They also treat the symptoms associated with depression, anxiety, and other psychological disorders that otherwise are not improving with just therapy and lifestyle changes. They may reduce the prevalence of the symptoms associated with these illnesses, but you may be wondering: do they really make you happy?


Antidepressants and How They Function

Antidepressants are medications specifically designed to target the levels of certain chemicals within the brain in an attempt to restore balance. These primarily include serotonin, norepinephrine, and dopamine. The type of antidepressant used determines the exact chemicals and neurotransmitters to be affected by the medication.

  • SSRIs, or selective serotonin reuptake inhibitors, are the class of antidepressants that are most common, with familiar medications falling into this category such as Prozac, Zoloft, Lexapro, and Celexa. These SSRIs function by increasing the levels of serotonin in the brain, inhibiting the reuptake of said chemical, and therefore allowing more of it to be available for use. This type of antidepressant is generally very effective when it comes to treating moderate to severe depression, especially when a chemical imbalance is contributing to an individual's symptoms. Serotonin is thought to be responsible for a good portion of mood regulation, as well as affecting a person's sleep habits, memory, and digestion and appetite. Low levels are generally detected in those experiencing depression, and balancing the amount of serotonin in the brain has been shown to improve symptoms. However, there is also too much of a good thing. Patients need to be closely monitored when taking prescription drugs that affect their serotonin levels, especially along with any dietary supplements or illegal drug use, to be sure that they do not overload their brain with the chemical and develop serotonin syndrome, which is a very serious and life-threatening condition. Those with too much serotonin in the body may experience sweating, confusion, increased blood pressure and heart rate, restlessness, digestive symptoms, headaches, and a loss of muscle control. Extremely high levels of serotonin can lead to seizures, unconsciousness, heart palpitations, and a high fever; at this point, the condition becomes life threatening and needs to be addressed and treated immediately.
  • SNRIs, or serotonin and norepinephrine reuptake inhibitors, inhibit the reuptake of both serotonin and norepinephrine. Norepinephrine, sometimes referred to as "noradrenaline," is both a neurotransmitter and a hormone that is responsible for the changes that take place when a person's "fight or flight" response is triggered. It causes an increase in blood pressure as well as heart rate, increase in blood glucose levels, and is also responsible during quick and intense norepinephrine spikes for causing panic attacks. For those with low levels of norepinephrine, they may experience symptoms of depression, anxiety, migraines, brain fog, lethargy, memory problems, low blood sugar levels, sleep issues, lack of arousal or interest, and even conditions such as restless leg syndrome and fibromyalgia. All of these symptoms, as well as the overall levels of norepinephrine naturally produced within your body can be worsened by poor nutrition, chronic stress, and taking certain medications, such as Ritalin. Levels that are too high can be caused by improper medication dosages, obesity, and tumors on the adrenal glands that regulate these hormones. Symptoms of excessive norepinephrine in an individual can be indicated by increased levels of anxiety, high blood pressure, headaches, heart palpitations, and increased sweating.


  • Bupropion, mainly known by its brand name of Wellbutrin, is an antidepressant that functions as an NDRI, or a norepinephrine-dopamine reuptake inhibitor. This means it only affects the levels of dopamine and norepinephrine available for use, and has no effect on the levels of serotonin within the body. It's prescribed for treating both depression as well as aiding in smoking cessation due to its effects on blocking nicotinic receptors. Dopamine is a neurotransmitter nicknamed as the "feel-good hormone," and it is responsible for affecting mood, memory, movement, and other factors of our wellbeing. Low levels of dopamine have been associated with muscle spasms, tremors, and cramps, as well as general aches and pain. Lower levels can also cause stiffness, acid reflux, difficulty eating, difficulty swallowing, constipation, trouble balancing, trouble focusing, sleep issues, mood swings, lethargy, fatigue, a lack of motivation, anxiety, sadness, suicidal thoughts, hopelessness, delusions, hallucinations, and low sex drive. A deficiency of dopamine can be caused by multiple factors including certain pre-existing health conditions, an unhealthy diet, drug abuse, and even obesity.

Though it does not alone cause certain illnesses, this deficiency is often associated with depression, Alzheimer's, Parkinson's disease, schizophrenia, addiction, ADHD (attention deficit hyperactive disorder), and psychosis. Some of the symptoms of high levels of dopamine include increased pleasure (hence it being the "feel good" hormone), increased cognitive speed and performance, anxiety, agitation and restlessness, high levels of energy, increased libido, mania, insomnia, paranoia, an increase in productivity and organized thought, social- and reward-seeking behaviors and impulses, or stress brought on by a dopamine-triggered release of adrenaline.

  • Tricyclic antidepressants are another class of antidepressants that function very similarly to SNRIs, by blocking the reuptake of serotonin and norepinephrine, but they differ in that they also block acetylcholine, which is a neurotransmitter affecting pain response in the body, muscles contractions, and the regulation of certain sleep functions. This type of medication is used for depression, but may also be prescribed for obsessive compulsive disorder. Some off-label uses include reducing the symptoms of chronic pain, insomnia, IBS (irritable bowel syndrome), bulimia and anorexia nervosa, bipolar disorder, anxiety, and panic disorder. Though less commonly prescribed compared to SSRIs and SNRIs, tricyclic antidepressants are generally used when these other medications are not proving to be beneficial in relieving symptoms.
  • MAOIs, or monoamine oxidase inhibitors, are the very first antidepressant ever created, and have since been replaced with much safer options (such as those mentioned above) with less side effects. Monoamine oxidase is an enzyme that assists in removing serotonin, norepinephrine, and dopamine from the brain. MAOIs function by preventing the action of the monoamine oxidase and therefore allow for more of the chemicals to be available for use within the body. Due to MAOIs also affecting other factors within the brain as well as the digestive tract, these types of antidepressants are prone to causing numerous side effects compared to the other classes, and often even require dietary restrictions to take safely. They also have a high risk of dangerous side effects occurring when mixed with other medications.
  • SARIs, or serotonin antagonist reuptake inhibitors, are technically antidepressant medications as well, but they are generally prescribed for other conditions, such as insomnia and anxiety. These medications are similar to SSRIs in that they preventing the reuptake of serotonin in the brain, but they more specifically target the 5HT2a receptor responsible for serotonin reuptake and block the transporter protein that allows this to occur. The most common medication in this category is trazodone, and though it may not always be prescribed for depression itself, it is commonly used for those experiencing sleep troubles and in conjunction with other antidepressant medications.

Common Mental Health Issues Treated with Antidepressants

Antidepressants are obviously prescribed most often for treating the symptoms of depression, anxiety, and major depressive disorder. However, due to the chemical makeup of the brain and how these affect various factors in a person's psychological and mental health experiences, antidepressants may also be prescribed for treatment in the following conditions:

  • OCD (Obsessive Compulsive Disorder)
  • Panic disorder
  • Anxiety
  • Severe Phobias
  • Insomnia
  • Eating disorders
  • PTSD (Post-Traumatic Stress Disorder)
  • Non-neuropathic chronic pain conditions
  • Bedwetting (in children)


Antidepressants Used with Therapy

For the greatest potential success in treatment and recovery from unpleasant mental health conditions, antidepressants are often used alongside therapy and counseling. Medications may be capable of reducing symptoms and allowing a person to function better in their daily lives, but often the underlying causes need to be addressed in order for the conditions to be truly alleviated and help a patient become happier, healthier, and more satisfied with their lives. Simply "taking a happy pill" will not always do the trick, and seeking the help of a licensed, trained, and experienced professional can assist in addressing underlying causes and improving the overall treatment process.

Non-Medicinal Methods of Feeling Happier

There are methods for becoming happier without resorting to prescribed medications, and for some, these options will greatly help out with their particular set of symptoms.

Diet and Exercise

The first step in feeling better mentally can often be to start feeling better physically. Being sure to address any health problems with your physician ensures that you'll be in the best possible condition for working on your mental state and alleviating any underlying causes that may be contributing to a lack of energy and joy in your life.

Once significant physical health conditions have been ruled out, your mood and overall wellbeing can be greatly improved with a healthier diet and regular exercise. Neither of these has to be pushed to the extremes, but even small changes can lead to signs of improvement for some individuals. Feeling better about yourself and getting your body functioning as well as it possibly can makes every day significantly easier and greatly reduces stress levels for most.

If you're taking care of yourself as well as possible and the symptoms of anxiety, sadness, or depression still linger, adding in antidepressant medications (and often therapy as well) may be just what you need to get that extra boost in adjusting the chemicals in your brain and resolving the rest of your symptoms.

A Positive Attitude

Does smiling make you happy? There are many people that praise the wonders of optimism and positive thinking. "Positive Activity Interventions" are a less formal idea of treatment for depression and focus on making intentional thoughts and behaviors of a positive nature a regular occurrence in your daily life. Gratitude, optimism, participating in random acts of kindness, and being kind to yourself fall into this mindset that some use to alleviate symptoms, and apparently it can work! Increased positivity has been linked to far more success in relationships, careers, and other goals one may set out to accomplish. It may not be appropriate for all individuals, but for some it may work well alone or in conjunction with medicinal treatment.


Though this form of "I think, therefore I am" in regards to happiness may work for some, those with more prominent symptoms and overwhelming anxieties can be even further harmed by trying to force positive emotions instead of acknowledging their fearful and depressed true state. Forced positivity is considered a form of "self-deception" in these cases and can actually worsen symptoms as the brain takes on even higher stress levels by trying to be forced into doing something that it reasons does not even make any sense alongside all of the very harsh conditions of reality it is already experiencing.

Convincing yourself that you're truly happy in the face of some very serious symptoms and life events is the exact same as suppressing significant mental health conditions that truly need treatment to avoid worsening. This is especially true in the cases of those with naturally low self-esteem. Those who may already think better about themselves outside of their depressive symptoms are easily brought back up to their natural state of feeling good about both themselves and their lives and futures.

Some people function better by dwelling on the negative, worrying and therefore overthinking and finding resolutions to their fears (which helps them to have a better sense of preparedness in the face of conflict), and using negative aspects to better themselves and prepare for the worst. People with chronic anxiety have been proven, due to this constant rumination, to be better at making quick and efficient decisions and handling catastrophic situations compared to those who are generally more happy and not having to deal with such concerns all the time.


Having a great support system is always key to navigating the ups and down of life. Having healthy relationships with your friends, family, and a significant other can greatly impact how you're able to deal with negative emotions and overcome the trials everyone eventually has to face at some point. Everyone needs someone that they can put their trust into and confide in when times get rough. Holding in all of your worries and negative thoughts only worsens them and brings on even more stress as you isolate yourself from those around you. This is why talk therapy is such an effective tool for mild depression all the way up to severe mental health conditions.

For many, love can make you happy, and it comes in many shapes and forms. Having people or even pets around you to turn to in times of sadness or crisis alleviates the beliefs of being entirely alone, which often amplify the symptoms of depression and other mental health concerns. These close loved ones are available to offer you comfort, a voice of reason, a shoulder to lean on, or sometimes just an ear to hear you out and help you to express yourself by venting.


As beneficial as a good support system and healthy relationships may be, they may not solve everything if your symptoms of depression and anxiety are significant enough. However, receiving professional treatment via therapy or medications is only further benefited by having those at home to love and support you through the process of getting back on your feet.

Seeking Further Help

Prescription medications may or may not be the appropriate fit for every single person struggling with feelings of sadness, hopelessness, loneliness, or anxiety. If you are curious to find out more information on how medications may benefit your particular situation, are interested in seeking professional counseling for your concerns, or simply would like to speak to a trained professional about all of these factors and what your best options for next steps may be, BetterHelp has professionals available via its online therapy resources that can be accessed online on your computer or phone from the comfort of your own home and on whatever schedule best suits your needs and lifestyle.

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